Pike-Overzet, K.

expression vector development therapy t-cell gene therapy t-cell development figure level patient rearrangement blood analysis leukemia integration number protein lentiviral insertion lmo 2 il 2rg receptor t-all study t cells oncogene stage hematopoietic transfer b cells 34+ factor transduced cluster thymocyte insertional mutagenesis trial cd 34+ cells murine gene expression result sequence transplantation marrow lineage transcription immunodeficiency chain mutation transgene x-linked model mouse b-cell rag 1 animal sample virus promoter mef 2c sffv-rag recombination probe bone marrow chapter region insertional schmidt m science von kalle c experiment lymphoid spleen transduction reconstitution t cell development genome system activity table