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cancer breast mutation breast cancer family wild-type e-cadherin expression migration study breast cancer cases cell lines chek 2 protein variant control table brca 1 carriers allele carrier brca 1 patient tumor stage analysis breast cancer risk breast cancers susceptibility breast cancer cells identi colorectal cancer research association colorectal university breast cancer res mda-mb identi fied frequency kras-variant department sequence genet migration capacity capacity institute +++ genetic variant allele fication signi netherland cohort subject pathway center phenotype transcript difference luminal oncogenic motility erasmus university index subtype inactivation cell line status cell migration hollestelle carcinoma cancer cell lines rotterdam basal gene mutation hypermethylation distance meijers-heijboer breast cancer susceptibility cell motility
9 Most Recent Publications
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E-cadherin promotor methylation and mutation are inversely related to motility capacity of breast cancer cells
(Article)
Horssen, R. van Hollestelle, A. Rens, J.A.P. Eggermont, A.M.M. Schutte, A.E.M. Hagen, T.L.M.T. |
2012-11-01
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Prevalence of the variant allele rs61764370 T>G in the 3′UTR of KRAS among Dutch BRCA1, BRCA2 and non-BRCA1/BRCA2 breast cancer families
(Article)
Hollestelle, A. Pelletier, C. Aulchenko, Y.S. Martens, J.W.M. Ouweland, A.M.W. van den Weidhaas, J. Hooning, M. Crepin, E. Schutte, A.E.M. Look, M.P. Collée, J.M. Nieuwlaat, A. Dorssers, L.C.J. Seynaeve, C.M. |
2011-07-01
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Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines
(Article)
Hollestelle, A. Nagel, J.H.A. Riaz, M. Koopman, D.G. Hagen, T.L.M. ten Leeuw, B. de Zwarthoff, E.C. Teunisse, A. Spek, P.J. van der Klijn, J.G.M. Dinjens, W.N.M. Ethier, S.P. Smid, M. Clevers, H.C. Jochemsen, A.G. Bakker, M.A. den Foekens, J.A. Martens, J.W.M. Schutte, A.E.M. Lam, S. Elstrodt, F. Wasielewski, M. Ng, S.S. French, P.J. Peeters, J. Rozendaal, M.J. |
2010-05-01
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Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2
(Article)
Ahmed, S. Thomas, G. Eccles, D. Sigurdson, A.J. Doody, M. Bhatti, P. Alexander, B.H. Hooning, M. Ouweland, A.M.W. van den Oldenburg, R. Schutte, A.E.M. Hall, P. Czene, k. Evans, D.G. Liu, J. Li, Y. Elliott, G. Brock, I. Reed, M.W.R. Shen, C.Y. Yu, J.C. Hsu, G.-C. Chen, S.-T. Anton-Culver, H. Fletcher, O. Ziogas, A. Andrulis, I.L. Knight, J.A. Beesley, J. Goode, E.L. Couch, F.J. Chenevix-Trench, G. Hoover, R.N. Ponder, B.A.J. Hunter, D. Johnson, N. Pharoah, P.D.P. Dunning, A.M. Chanock, S.J. Easton, D.F. Dos Santos Silva, I. Peto, J. Stratton, M.R. Rahman, N. Jacobs, K. Prentice, R. Ghoussaini, M. Anderson, G.L. Rajkovic, A. Curb, J.D. Ziegler, R.G. Berg, C.D. Buys, S.S. McCarty, C.A. Feigelson, H.S. Calle, E.E. Thun, M.J. Healey, S. Diver, W.R. Bojesen, S.E. Nordestgaard, B.G. Flyger, H. Dörk, T. Schürmann, P. Hillemanns, P. Karstens, J.H. Bogdanova, N.V. Antonenkova, N.N. Humphreys, M.K. Zalutsky, I.V. Bermisheva, M. Fedorova, S. Khusnutdinova, E. Kang, D. Yoo, K.Y. Noh, D.Y. Ahn, S.H. Devilee, P. Asperen, C.J. van Platte, R. Tollenaar, R.A.E.M. Seynaeve, C.M. García-Closas, M. Lissowska, J. Brinton, L.A. Peplonska, B. Nevanlinna, H. Heikinen, T. Aittomäki, K. Blomqvist, C. Morrison, J. Hopper, J.L. Southey, M.C. Smith, L. Spurdle, A.B. Schmidt, M.K. Broeks, A. Hien, R.R. van Cornelissen, S. Milne, R.L. Ribas, G. Maranian, M. González-Neira, A. Benítez, J. Schmutzler, R.K. Burwinkel, B. Bartram, C.R. Meindl, A. Brauch, H. Justenhoven, C. Hamann, U. Chang-Claude, J. Pooley, K.A. Hein, R. Wang-Gohrke, S. Lindblom, A. Margolin, S. Mannermaa, A. Kosma, V.M. Kataja, V. Olson, J.E. Wang, X. Fredericksen, Z. Luben, R.N. Giles, G.G. Severi, G. Baglietto, L. English, D.R. Hankinson, S.E. Cox, D.G. Kraft, P. Vatten, L.J. Hveem, K. Kumle, M. |
2009-05-01
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Deleterious CHEK2 1100delC and L303X mutants identified among 38 human breast cancer cell lines
(Article)
Wasielewski, M. Hanifi-Moghaddam, P. Hollestelle, A. Merajver, S.D. Ouweland, A.M.W. van den Klijn, J.G.M. Ethier, S.P. Schutte, A.E.M. |
2009-01-01
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Anti-epithelial cell adhesion molecule antibodies and the detection of circulating normal-like breast tumor cells
(Article)
Sieuwerts, A.M. Kraan, J. Bolt, J. Spoel, P. van der Elstrodt, F. Schutte, A.E.M. Martens, J.W.M. Gratama, J-W. Sleijfer, S. Foekens, J.A. |
2009-01-01
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MDM2 SNP309 accelerates familial breast carcinogenesis independently of estrogen signaling
(Article)
Wasielewski, M. Nagel, J.H.A. Brekelmans, C.T. Klijn, J.G.M. Ouweland, A.M.W. van den Meijers-Heijboer, E.J. Schutte, A.E.M. |
2007-08-01
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The CHEK2 1100delC mutation identifies families with a hereditary breast and colorectal cancer phenotype
(Article)
Meijers-Heijboer, E.J. Moslein, G. Bos, R.R. van den Snoo, A. de Schutte, A.E.M. Franken, P.F. Fat, G.T. Jagmohan, S. Chapman, P. Brekelmans, C.T. Wijnen, J. Vasen, H. Lynch, H. Ouweland, A.M.W. van den Klijn, J.G.M. Hollestelle, A. Wasielewski, M. Fodde, R. Wagner, A. Elstrodt, F. Verkuijlen, P. Tops, C. Burn, J. |
2003-01-01
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Variants in CHEK2 other than 1100delC do not make a major contribution to breast cancer susceptibility
(Article)
Schutte, A.E.M. Meijers-Heijboer, E.J. Nathanson, K.L. Futreal, P.A. Stratton, M.R. Seal, S. Barfoot, R. Ouweland, A.M.W. van den Klijn, J.G.M. Easton, D.F. Wasielewski, M. Evans, D.G. Eccles, D. Weber, B.L. Rahman, N. Meijers, C. Lohman, F. |
2003-01-01
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