Mathot, R.A.A.

patient concentration study plasma pharmacokinetic variability model level value sample impdh ec-mp transplant transplantation group clearance mycophenolate mofetil table analysis mycophenolate treatment course method within-patient variability difference circuit docetaxel signi parameter transplant recipients dosing result mpa cl enteric-coated mycophenolate sodium midazolam morphine effect number mofetil population volume range activity mpa auc 0–12 recipient sampling predose mycophenolic impdh type 1 mycophenolic acid interindividual variability within-patient absorption cyclosporine signi ficantly impdh activity cancer failure expression ficant correlation 0–12 mpa clearance recovery rejection drug monitoring dosage ef ficacy strategy fluvoxamine liver transplant patients solution bsa-based dosing group figure exposure graft erasmu extracorporeal membrane oxygenation precision