Lohman, F.

cancer breast cancer breast variant family subject control r 117g breast cancer cases individual chek 2 brca 1 mutation susceptibility chek 2 variants kingdom i 157t sequence variant evaluation age 60 years breast cancer susceptibility control subjects breast cancer risk netherland genetic fha domain frequency study breast cancer incidence genet research variant ascertainment analysis li-fraumeni syndrome germline consortium 1100 delc syndrome binding family history america netherlands domain kinase america table evaluation pedigree phosphorylation case subjects control individuals dna damage response r 117a cancer research u.k r 145w population 1/723 control subjects checkpoint r 117g variant 723 control subjects contribution ascertainment chk 2 gene damage 2/737 brca 1/2-negative chk 2 brca 2 mutations allele 1/2-negative brca 1/brca 2-breast vahteristo protein genomic project wild-type institute linkage analyses dutch li-fraumeni