Fritz, H.

calpain subunit protein caspase 2 m ionomycin ionomycin activity variant apoptosi activation membrane addition localization result domain cleavage bcl -2 proteins concentration calpain subunits calcium bcl -2 cytochrome c release bcl-xl cytochrome ac 27p image antibody apoptotic intracellular fluorescence 80 k subunit interaction family study substrate cytochrome c m-calpain pathway cos 7 cells binding calpain activity increase k-eyfp death mitochondria release 30 min overexpressing subcellular subcellular localization enzyme ionomycin-induced nucleus calpastatin condition overexpressed cos 7 ionomycin addition contrast chimera n-terminal biochem fraction panel di-iib preincubation n terminus cytoplasmic 80 k-eyfp apoptotic pathway mechanism helice filter cell death cleavage sites table i autolysi calpain activation n-terminal helices residue