Barfoot, R.

cancer breast cancer breast family brca 1 brca 2 mutations mutation chek 2*1100delc variant individual 2*1100delc control chek 2 frequency susceptibility subject breast cancer risk netherland genetic r 117g breast cancer susceptibility research analysis sequence breast cancer cases study allele nature population linkage breast cancer incidence chek 2 variants kingdom control individuals li-fraumeni syndrome family history carrier brca 2 i 157t kinase america syndrome table variant evaluation age 60 years breast cancer unselected control subjects analyses series chk 2 genomic checkpoint institute pedigree damage group chromosome protein fha domain dutch marker genome 1100 delc mutation genet chek 2*1100delc variant variant ascertainment germline consortium 1100 delc binding fi rst america netherlands domain heteroduplex analysis estimate segregation evaluation phosphorylation model case subjects