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disease study alzheimer dementia nsaid effect exposure subject trial estrogen cohort women interview rotterdam association prevention rotterdam study therapy result duration month replacement nsaid use population antihypertensive table baseline number patient evidence factor group information prescription treatment function neurology hormone hormone replacement therapy brain control estrogen replacement therapy health follow-up source analysis incident onset incident alzheimer agent aspirin blood chapter education population-based blood pressure pressure benzodiazepines problem diagnosis pharmacy drug use review assessment period incidence hypertension t veld ba memory risk reduction reference hofman research risk factors systolic blood pressure reduction ziekte van alzheimer carotid sample mechanism