Hernández A.V.

trial patient effect covariate outcome subgroup treatment analysis adjustment predictor model sample size study injury covariate adjustment subgroups sample treatment effect subgroup analysis result reduction /iiia analyses number stroke baseline randomized power head injury brain injury heart receptor subgroup analyses death prognostic characteristic brain table treatment effects blocker chapter interaction group age subgroups syndrome strategy benefit regression baseline characteristics journal percent value 30 days pre-specified covariate effect imbalance sample size requirements report method prevalence difference steyerberg ew score randomised type i error comparison steyerberg tbi trials event non-st-segment elevation increase glycoprotein lancet hypotension heart failure infarction hypoxia elevation review cardiol