Jansen, J.

patient thyroid mct 8 hormone transporter mutation protein uptake hmct 8 thyroid hormone expression transfected t 3 uptake transport figure level visser jeg 3 cells serum metabolism control fibroblast monocarboxylate result psychomotor retardation friesema brain activity monocarboxylate transporter 8 family chapter mct 8 patients pcdna function membrane psychomotor retardation endocrinol development study efflux cos 1 cells transfection thyroid hormone transporter deiodinase visser tj plasma membrane increase mct 8 mutations plasma friesema ec incubation patient p 4 intracellular hmct 10 cells transfected mutant jansen j jansen 1/1 iodothyronine medium tissue neuron serum t 3 wild-type x-linked psychomotor retardation mct 8 gene t 4 uptake domain effect iodothyronines thyroid hormone action concentration kester mh splice syndrome 3 activity liver thyroid hormone transporters