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expression erythroid protein gata 1 factor level transcription promoter figure blood analysis differentiation binding control globin number mouse result mutation embryo development study activity erythropoiesi cd 70tg mice treatment region liver patient sequence progenitors b-globin gata 1 expression wild-type trail erythroid differentiation prmt 1 antibody culture assay response target function experiment erasmus mc hemoglobin group cancer erythroid cells locus 59 hs 5 hematopoietic ifn -␥ adult table pemetrexed regulation phenotype knockdown erasmu erythroid progenitors thalassemia c /ebpg speci volume spleen signi effect fication heart tissue activation transgene nsclc university ms 275 variant motif sox 2 tpmt gene promoter
10 Most Recent Publications
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KLF10 gene expression is associated with high fetal hemoglobin levels and with response to hydroxyurea treatment in -hemoglobinopathy patients
(Article)
Borg, J. Phylactides, M. Hou, J. Karkabouna, S. Lappa-Manakou, C. Özgür, Z. IJcken, W.F.J. van Lindern, M.M. von Grosveld, F.G. Georgitsi, M. Kleanthous, M. Philipsen, S. Bartsakoulia, M. Patrinos, G.P. Tafrali, C. Lederer, C.W. Felice, A.E. Papachatzopoulou, A. Kourakli, A. Stavrou, E.F. Christou, S. |
2012-10-01
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Expression profiling-based subtyping identifies novel non-small cell lung cancer subgroups and implicates putative resistance to pemetrexed therapy
(Article)
Hou, J. Lambers, M.E.H. Den Hamer, B. Bakker, M.A. den Hoogsteden, H.C. Grosveld, F.G. Hegmans, J.P. Aerts, J.G.J.V. Philipsen, S. |
2012-01-01
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Chronic IFN-γ production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU.1 axis
(Article)
Libregts, S.F. Gutiérrez, L. Bruin, A.M. de Wensveen, F.M. Papadopoulos, P. IJcken, W.F.J. van Özgür, Z. Philipsen, S. Nolte, M.A. |
2011-09-01
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The DNA binding factor Hmg20b is a repressor of erythroid differentiation
(Article)
Esteghamat, F. Dijk, T.B. van Horos, R. Pourfarzad, F. Lindern, M.M. von Philipsen, S. Braun, H. Dekker, S. Linden, R. van der Hou, J. Fanis, P. Demmers, J.A. IJcken, W.F.J. van Özgü, Z. |
2011-09-01
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Differential regulation of sense and antisense promoter activity at the Csf1R locus in B cells by the transcription factor PAX5
(Article)
Ingram, R.M. Valeaux, S. Bonifer, C. Wilson, N.K. Bouhlel, M.A. Clarke, D. Krüger, I. Kulu, D. Suske, G. Philipsen, S. Tagoh, H. |
2011-07-01
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Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes
(Article)
Engelen, E. Akinci, U. Demmers, J.A. Rijkers, E.J. Bhattacharya, S. Philipsen, S. Pevny, L.H. Grosveld, F.G. Rottier, R. Lenhard, B. Poot, R.A. Bryne, J.C. Hou, J. Gontan, C. Moen, M.H. Szumska, D. Kockx, C. IJcken, W.F.J. van Dekkers, D.H. |
2011-06-01
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Erythroid phenotypes associated with KLF1 mutations
(Article)
Borg, J. Patrinos, G.P. Felice, A.E. Philipsen, S. |
2011-05-01
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Functional and sequence analysis of human neuroglobin gene promoter region
(Article)
Zhang, W.Y. Tian, Z. Sha, S. Cheng, L.Y.L. Philipsen, S. Tan-Un, K. |
2011-04-01
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Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach
(Article)
Giardine, B. Borg, J. Costa, F.C. Faustino, P. Fedosyuk, H. Felice, A.E. Francina, A. Galanello, R. Gallivan, M.V.E. Georgitsi, M. Gibbons, R.J. Giordano, P.C. Higgs, D.R. Harteveld, C.L. Hoyer, J.D. Jarvis, M. Joly, P. Kanavakis, E. Kollia, P. Menzel, S. Miller, W.G. Moradkhani, K. Old, J. Peterson, K.R. Papachatzopoulou, A. Papadakis, M.N. Papadopoulos, P. Pavlovic, S. Perseu, L. Radmilovic, M. Riemer, C. Satta, S. Schrijver, I.A. Stojiljkovic, M. Philipsen, S. Thein, S.L. Traeger-Synodinos, J. Tully, R. Wada, T. Waye, J.S. Wiemann, C. Zukic, B. Chui, D.H.K. Wajcman, H. Hardison, R. Maglott, D. Patrinos, G.P. Singleton, B.K. Anstee, D.J. Basak, A.N. Clark, B.H. |
2011-02-01
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Fetal globin expression is regulated by Friend of Prmt1
(Article)
Dijk, T.B. van Gillemans, N. Pourfarzad, F. Lom, K. van Lindern, M. von Grosveld, F.G. Philipsen, S. |
2010-11-18
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