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nherf nhe 3 protein nhe 3 activity nherf 1 activity nherf 2 ileum inhibition membrane effect study expression support regulation physiol absorption cgk ii mouse basal intestine nherf 2ϫ/ϫ mice jejunal jejunum blood cells fl uid absorption nherf -2 nhe 3 regulation tissue result figure exchanger level ileal chloride control -/- apical wt mice antibody stimulation domain donowitz change crypt secretion caco -2 cells experiment work-life tubule activation family epithelial balance blood border downloaded kidney colon transport ␣- md-g hco 3– secretion amount buffer autophosphorylation donowitz m analysis nhe 3 inhibition work-life balance satisfaction pdzk 1 presence erasmus mc erasmus univ rotterdam erasmu brush weinman model absence number nherf -1-deficient mice
10 Most Recent Publications
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NHERF2 is necessary for basal activity, second messenger inhibition, and LPA stimulation of NHE3 in mouse distal ileum
(Article)
Murtazina, R. Kovbasnjuk, O. Chen, T.E. Zachos, N.C. Kocinsky, H.S. Hogema, B.M. Seidler, U. Jonge, H.R. de Donowitz, M. |
2011-07-01
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Alterations in the proteome of the NHERF2 knockout mouse jejunal brush border membrane vesicles
(Article)
Donowitz, M. Singh, P. Broere, N. Smalley-Freed, W.G. Reynolds, A.B. Hubbard, A. Seidler, U. Weinman, E.J. Jonge, H.R. de Hogema, B.M. Li, X. Chakraborty, M. Chen, C.Y. Murtazina, R. Gucek, M. Cole, R.N. Zachos, N.C. Salahuddin, F.F. Kovbasnjuk, O. |
2011-06-01
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D-glucose acts via sodium/glucose cotransporter 1 to increase NHE3 in mouse jejunal brush border by a Na+/H+ exchange regulatory factor 2dependent process
(Article)
Lin, R. Murtazina, R. Li, X. Kovbasnjuk, O. Donowitz, M. Cha, B. Chakraborty, M. Sarker, R. Chen, T. Hogema, B.M. Jonge, H.R. de Seidler, U. Turner, J.R. |
2011-02-01
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Loss of PDZ-adaptor protein NHERF2 affects membrane localization and cGMP- and [Ca2+]- but not cAMP-dependent regulation of Na+/H+ exchanger 3 in murine intestine
(Article)
Chen, M. Sultan, A. Hogema, B.M. Jonge, H.R. de Seidler, U. Cinar, A. Yeruva, S. Riederer, B. Singh, A.K. Li, J. Bonhagen, J. Yun, C. Donowitz, M. |
2010-12-01
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Alterations in the proteome of the NHERF1 knockout mouse jejunal brush border membrane vesicles
(Article)
Donowitz, M. Singh, P. Broere, N. Smalley-Freed, W.G. Reynolds, A.B. Hubbard, A.L. Seidler, U. Weinman, E.J. Jonge, H.R. de Hogema, B.M. Li, X. Salahuddin, F.F. Chen, Y. Chakraborty, M. Murtazina, R. Gucek, M. Cole, R.N. Zachos, N.C. Kovbasnjuk, O. |
2010-11-01
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Lysophosphatidic Acid Stimulates the Intestinal Brush Border Na+/H+ Exchanger 3 and Fluid Absorption via LPA5 and NHERF2
(Article)
Lin, S. Yeruva, S. Hogema, B.M. Chun, J. Seidler, U. Yun, C.C. He, P. Singh, A.K. Zhang, H. Chen, M. Lamprecht, G. Jonge, H.R. de Tse, M. Donowitz, M. |
2010-02-01
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Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice
(Article)
Singh, A.K. Riederer, B. Kocher, O. Hogema, B.M. Seidler, U. Krabbenhöft, A. Rausch, B. Bonhagen, J. Lehmann, U. Jonge, H.R. de Donowitz, M. Yun, C. Weinman, E.J. |
2009-03-02
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Defective jejunal and colonic salt absorption and alteredNa +/H+ exchanger 3 (NHE3) activity in NHE regulatory factor 1 (NHERF1) adaptor protein-deficient mice
(Article)
Broere, N. Chen, M. Rausch, B. Weinman, E.J. Donowitz, M. Hubbard, A. Kocher, O. Jonge, H.R. de Hogema, B.M. Seidler, U. Cinar, A. Singh, A.K. Hillesheim, J. Riederer, B. Lunnemann, M. Rottinghaus, I. Krabbenhöft, A. Engelhardt, R. |
2009-03-01
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Urine electrolyte, mineral, and protein excretion in NHERF-2 and NHERF-1 null mice
(Article)
Cunningham, R. Esmaili, A. Shenolikar, S. Wade, J.B. Weinman, E.J. Brown, E. Biswas, R.S. Murtazina, R. Donowitz, M. Dijkman, H. Vlag, J. van der Hogema, B.M. Jonge, H.R. de |
2008-04-01
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Cystic fibrosis transmembrane conductance regulator activation is reduced in the small intestine of Na+/H+ exchanger 3 regulatory factor 1 (NHERF-1)- but not NHERF-2-deficient mice
(Article)
Broere, N. Hillesheim, J. Hogema, B.M. Tuo, B. Jorna, H. Houtsmuller, A.B. Shenolikar, S. Weinman, E.J. Donowitz, M. Seidler, U. Jonge, H.R. de |
2007-12-28
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