Vanin, E.

deletion sequence breakpoint probe fragment globin cluster result chromosome figure region family hybridization rearrangement event clone point hpfh 1 order nature p-globin deletion event &3-thal research ill-barn hi fragment restriction amount hpfh 2 cosmid study phage orkin replication eco ri alui family sequences acids research dna sequences sph 2.5 probe alu sequence exchange 2.5 deletion joints mechanism dna loops relationship genomic dna p-globin gene flavell breakage reunion event chromosome 11. nucleotide thalassaemia van der ploeg kpni family sequence number hpfh 1 deletion length p-globin gene cluster hpfh 2 homozygote restriction enzyme sites fritsch y &3-thal 1 alu family sequence sph 2.5 nonhomologou figure 3 persistence nucleotide sequences thalassemia distance cosmid clones anchorage hybridization studies genomic attachment points anchorage points enzyme hybridize hemoglobin