Groffen, J.

probe deletion result sequence chromosome breakpoint cluster fragment region family p-globin event deletion event research hybridization globin rearrangement alui family sequences acids research sph 2.5 probe 2.5 dna loops p-globin gene chromosome 11. thalassaemia p-globin gene cluster kpni family sequence number amount cosmid study order sph 2.5 hybridization studies attachment points point ecori restriction j probe y-globin gene probe example dnase i expression chromosome 11 deletion events patient intensity 11. restriction sites p-globin gene probe clone attachment hybridized vanin grain chromosomal nature 2.1 heterozygote cosmid library 30 kbp j-globin cluster 3.3 genomic dna dnase erythropoetic cells globin genes p-globin cluster kioussi library 99 kbp embo fellowship grosveld replication reunion event digest y-gene value y 8f 2 yf 8vthals 1