Guetens, G.

melphalan tumor perfusion patient hepatic liver response il -2 cancer treatment concentration metastase study hepatic perfusion limb perfusion colorectal effect catheter hypoxic hepatic perfusion toxicity necrosis leakage hepatic artery tumor necrosis factor artery portal vein portal tissue huvec result oncol response rates minute eggermont balloon netherland survival month growth technique histamine combination van tiel st evect control hepatic metastases disease bile duct necrosis melanoma sarcoma procedure uptake hypoxic tumor response factor volume muscle medium increase caval permeability circuit irresectable liver metastases libutti sk method group model -175 vessel assay 30 minutes tumor cells grade colorectal cancer operation irresectable liver metastases cancer institute value infusion