Tol, J. van

motif interaction fxxlf ar fxxlf motif binding ar lbd lxxll receptor peptide coactivator residue • ar recognition androgen fxxlf motif groove protein yeast lxxll motifs experiment domain f 23l wild-type structure hep 3b cells androgen receptor model substitution recognition activity ␣ lbd acid residues endocrinol positions ϩ1 ar lbd interaction ␤- galactosidase activity f residues tif 2 boxes position dubbink fusion expression variant k 720 mutation transcriptional november downloaded september chain analysis coactivator lxxll motifs ar coactivator groove e 897 tif 2 motifs luciferase activity yeast two-hybrid experiments function two-hybrid ligand activation affinity r 726 ar ntd coactivator groove crystal system result charge dissociation luciferase blot analysis side chains fxxlf motifs assay one-hybrid sequence n /c interaction hydrogen bonds hydrogen k 717