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ghrelin insulin administration concentration insulin sensitivity effect level study glucose subject sensitivity placebo ag ϩ uag kojima m endocrinology change kangawa k baseline insulin resistance fi rst hour metabolism acylated acylated ghrelin endocrinol combination serum gh-deficient subjects secretion metab insulin concentration injection journal kangawa hosoda h unacylated ghrelin study medication kojima obesity lunch insulin concentrations replacement dose receptor increase growth serum glucose levels hormone plasma ghigo resistance gauna gh-deficient result ghigo e october unacylated day 1 comb administration day 4 peptide hosoda • effects diabetes co-administration replacement uag levels figure study drug nakazato m uag 200 mg ffa levels ghrelin concentrations downloaded ghrelin levels 2– 6 h serum insulin levels human fasting assay medication breakfast
4 Most Recent Publications
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In vitro and in vivo stability and pharmacokinetic profile of unacylated ghrelin (UAG) analogues
(Article)
Julien, M. Kay, R.G. Delhanty, P.J.D. Allas, S. Granata, R. Barton, C. Constable, S. Ghigo, E. Lely, A.J. van der Abribat, T. |
2012-11-20
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Effects of acute administration of acylated and unacylated ghrelin on glucose and insulin concentrations in morbidly obese subjects without overt diabetes
(Article)
Kiewiet-Kemper, R.M. Aken, M.O. van Lely, A.J. van der Weerd, K. van der Uitterlinden, P. Themmen, A.P.N. Hofland, L.J. Rijke, Y.B. de Delhanty, P.J.D. Ghigo, E. Abribat, T. |
2009-11-27
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Administration of acylated ghrelin reduces insulin sensitivity, whereas the combination of acylated plus unacylated ghrelin strongly improves insulin sensitivity.
(Article)
Gauna, C. Meyler, F.M. Janssen, J.A.M.J.L. Delhanty, P.J.D. Abribat, T. Koetsveld, P.M. van Hofland, L.J. Broglio, F. Ghigo, E. Lely, A.J. van der |
2004-10-01
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Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans.
(Article)
Broglio, F. Gottero, C. Prodam, F. Gauna, C. Muccioli, G. Papotti, M. Abribat, T. Lely, A.J. van der Ghigo, E. |
2004-06-01
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