Molenaar, L.

chromosome sample ratio genomic array ampli clone microdissected analysis fication genome array cgh figure hybridization control change acids research genomic dna copy-number log 2 ratio log 2 ratios tumor method genomic hybridization microarray region level number reference amplification model amount ampli fied copy-number changes table detection deletion tissue chromosomal unampli research genes chromosomes cancer oligonucleotide approach 29-ampli result signi sequence alteration material pilot intercept genomic dna samples threshold cancer mucosa resolution chromosome 5 chromosome x study marker microdissected samples reaction regression model ampli fication smith algorithm 1000 microdissected cells 29-amplified control dna samples bioprime 1 dna variability unampli fied dna f 29-ampli dna subset ficant pilot subset samples protocol subchromosomal center