Hewison, M.

glucocorticoid activity 11␤- expression osteoblast culture differentiation osteoblast differentiation effect synovial fi broblasts treatment il -1β dehydrogenase promoter induction dexamethasone hsd 11b promoter flammatory 11␤- hsd 1 sv-hfo broblast cortisol cytokine level cortisone 11β- hsd 1 hydroxysteroid synovial nondifferentiating proin flammatory cytokines alp activity mineralization protein study dex treatment control adipocyte endocrinol ϯ sem result nondifferentiating osteoblasts value regulation region flammatory cytokines c /ebp increase medium mg -63 cells downloaded sv-hfo cells arthritis tissue presence mrna expression bone loss production mechanism nondifferentiating cultures hewison m p <0.05 absence primer fi broblasts combination sv-hfo culture -1β+dex pro-in flammatory cytokines foreskin fi broblasts dna content flammation eijken october action cooper patient 11␤ factor beta-hydroxysteroid response