Ohneda, K.

gata 1 erythroid factor expression transcription differentiation protein blood level figure lcr-g erythropoiesi hematopoietic transgene development ko-tx erythroid cells orkin progenitors erythroid differentiation number mouse control result mutation analysis promoter rescue gata 2 regulation ko-tx mice adult spleen orkin sh transcription factors lineage binding megakaryocyte activity ko-mx 1-null gata 1-null mutation interaction treatment finitive erythropoiesis region study hrd-g -finger signi ficantly transcription factor gata embo j n -finger tx treatment stage finitive function domain globin signi phenotype gata 1. wt mice gata 1 function terminal maturation erythroblast erythroid progenitors speci sequence count ko-mx mice gata 1 activity erasmus mc anemia terminal erythroid differentiation liver hematopoiesi liver cells phz treatment