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virus influenza protein influenza virus class infection vaccine presentation antigen iscom antibody peptide epitope b-lcl mutation assay b-lcl cells hla-b target cells processing patient np /b ctl clone reassortant hla-a target cytotoxic influenza viruses response ¯uenza r 384g mutation recognition serum sequence exogenou ctl assays molecule nucleoprotein h 3n viruses elisa result rmaha protein medium strain chapter figure analysis incubation rmaha season reassortant viruses pathway segment influenza virus b cytotoxic t lymphocytes ctl clone presence np /a surface region hi assay lymphocytes control immunity surface glycoproteins antigenic production inhibitor study ¯uenza virus ctl epitopes hla-a 3 influenza virus infection embryonated chicken eggs srywairtr <10 polymerase encoding osterhau matrix