Nieuwkoop, N.J.

virus influenza influenza virus protein epitope mutation class response hla-b peptide target cells np /b ctl cytotoxic presentation b-lcl r 384g mutation iscom target antigen b-lcl cells vaccination hla-a clone substitution np 383391 epitope sequence control cytotoxic t lymphocytes recognition vaccine r 384g substitution influenza viruses group ltx recipients processing ¯uenza infection antibody recipient rimmelzwaan virol patient ¯uenza virus nucleoprotein plasmid osterhau result assay titer immunol individual rmaha virus-specific medium lymphocytes strain ctl assays molecule rmaha protein exogenou acid substitutions season release 293 t cells rpmi 1640 medium np /a pbmc cultures fluenza stimulation percentage h 3n viruses bm 36´1 cells t-cell ctl clone ctl response position ctl epitopes fi tness study hla-a 3-