Peeters, M.Y.

propofol clearance children model patient propofol clearance neonate pharmacokinetic infusion allometric study blood liver blood flow value adult midazolam sedation level range parameter concentration surgery propofol infusion litre covariate table allometric model sorbitol fixed-exponent allometric model population analysis sedative bodyweight netherland liver function paediatric variability infant administration equation propofol pharmacokinetics error anaesth knibbe comfort sample cpk levels percentage errors objective function craniofacial surgery hepatic pharmacol score comfort behaviour scale group observation method weight postnatal inter-individual variability care unit colleague effect department hospital propofol infusion syndrome result objective maturation inter-individual volume behaviour litre à1 scale output propofol concentrations preterm postmenstrual month