Knibbe, C.A.

model patient children morphine clearance population study propofol neonate covariate concentration dataset pharmacokinetic parameter value paediatric distribution dosing analysis infant allometric sedated result bodyweight postnatal age scale table method range allometric model pharmacol function effect score information preterm prediction volume variability off-label parameter estimates covariate model infusion sedated patients postnatal evaluation validation estimate propofol clearance pharmacokinet level adult nurse postmenstrual age observation sedation metabolite research error figure pharmacokinetic model procedure number surgery 10 days knibbe group term neonates maturation change regimen weight influence trial hospital approach netherland elimination equation sample