Uitterlinden, E.J.

effect cartilage glucosamine study patient glcn-hcl osteoarthritis glcn- expression concentration chondrocyte culture gene expression 5 mm glcn-hcl trial explant experiment addition control condition placebo difference result medium group 0.5 articular treatment womac activity culture medium baseline sample osteoarthritic matrix knee oa chapter 5 mm gluc 5 mm glcn-s production level glucosamine sulphate change analyses analysis catabolic glcn-ac synovial hip oa anabolic amount degradation score rovati lc sulfate orth mw caron jp sulphate synthesis progression synovium articular cartilage outcome control condition tissue rheum function ënten glucose aggrecan subgroup peters tl adamt value down-regulation van osch gj arthritis synovial fluid rovati knee osteoarthritis