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scopus: 6602183932

Agtmael, M.A. van

(Michiel Agtmael)


patient protease monotherapy therapy resistance treatment study infection agent lopinavir inhibitor failure mutation ef ficacy haart mycobacterium avium mycobacterium avium concentration lpv /r monotherapy combination hiv-rna trial clarithromycin analysis activity virologic failure amikacin ficacy mycobacterial liposomes regimen result growth virologic lpv /r antimycobacterial effect /liter protease inhibitor mutations 24 weeks bactericidal exposure antimycobacterial agents ethambutol mycobacteria signi 21 days l 76v antimicrob protease inhibitor monotherapy addition susceptibility chemother 10 days virus strain sample m 46i ritonavir-boosted therapy failure agents chemother number delivery mycobacterial infections bactericidal activity 50 copies /ml mac infection /ritonavir drug delivery phase substitution antimicrobial plasma organ 16 mg /liter lopinavir resistance as-treated analysis antiretroviral mouse model




4 Most Recent Publications

Failure of treatment with first-line lopinavir boosted with ritonavir can be explained by novel resistance pathways with protease mutation 76V (Article)
Nijhuis, M. Wensing, A.M.J. Bierman, W.F.W. Jong, D. de Kagan, R. Fun, A. Jaspers, C.A.J.J. Schurink, K.A.M. Agtmael, M.A. van Boucher, C.A.B.
2009-09-01
HIV monotherapy with ritonavir-boosted protease inhibitors: A systematic review (Article)
Bierman, W.F.W. Agtmael, M.A. van Nijhuis, M. Danner, S.A. Boucher, C.A.B.
2009-01-28
Targeted drug delivery to enhance efficacy and shorten treatment duration in disseminated Mycobacterium avium infection in mice (Article)
Steenwinkel, J.E.M. de Vianen, W. van Kate, M.T. ten Verbrugh, H.A. Agtmael, M.A. van Schiffelers, R.M. Bakker-Woudenberg, I.A.J.M.
2007-11-01
Antimycobacterial agents differ with respect to their bacteriostatic versus bactericidal activities in relation to time of exposure, mycobacterial growth phase, and their use in combination. (Article)
Bakker-Woudenberg, I.A.J.M. Vianen, W. van Soolingen, D. van Verbrugh, H.A. Agtmael, M.A. van
2005-06-01