Ziel-van der Made, A.C.

prostate cancer psa-cre prostate cancer epithelial tumor month e 17k substitution mutation akt 1 expression 14 months inactivation control epithelial cells model mouse tissue development hyperplasia prostate lobes prostate epithelial cells apoptosi proliferation luminal epithelial cells 5 months patient pik 3ca proliferation rate adenocarcinoma staining prostate cancer development pten +/à mice recombination tumor development pten inactivation gland sample promoter hyperplasia /pin lesions substitution phospho-akt pik 3r control mice carcinoma lesion stage number luminal suppressor study prostate-specific growth tumours pten recombination cre expression pten exon 5 pleckstrin homology domain psa promoter change pin lesions fragment prostate weight pathway monoallelic cytokeratin www.aacrjournals.org function 9 months pten expression antibody weight littermate control littermates survival dysplasia adult caspase -3-positive cells van der korput biallelic