Autar, B.

prostate cancer psa-cre epithelial tumor month 14 months expression control prostate cancer epithelial cells model inactivation mouse development hyperplasia prostate lobes prostate epithelial cells tissue apoptosi proliferation luminal epithelial cells 5 months proliferation rate staining prostate cancer development pten +/à mice recombination tumor development pten inactivation gland hyperplasia /pin lesions control mice promoter phospho-akt lesion number luminal suppressor prostate-specific carcinoma adenocarcinoma pten recombination cre expression pten exon 5 psa promoter stage change pin lesions fragment prostate weight monoallelic study cytokeratin www.aacrjournals.org function 9 months antibody weight littermate control littermates dysplasia pten expression caspase -3-positive cells biallelic adult van der korput prostate cancer model androgen mutation section androgen receptor staining deletion prostate lobe pten gene apoptotic index recombined band genomic dna receptor brdurd-positive cells