Duijn, P.W. van

cancer prostate expression tumor prostate cancer chapter regulation protein 27kip pi 3k cycle figure analysis pathway lncap kinase inactivation mutation lncap /pten cells p 27kip expression pten expression function suppressor study control p 27kip phosphorylation pten inactivation deletion transcription factor number activity q-wpr psa-cre level skp 2 growth sample mouse pc 3 cells apoptosi progression chromosome model tissue phosphatase development target effect mechanism /pten proliferation assay pten exon 5 pseudogene cell cycle arrest activation cyclin epithelial carcinoma arrest ratio androgen sirna xenograft method process genomic cell lines pc 346 cells change cell cycle regulation pten gene alteration month cell cycle amplification disease genet