Jongh, J. de

labour patient amoxicillin pharmacokinetic concentration study model women population onset postpartum period blood antibiotic postpartum effect parameter sample volume analysis distribution pregnancy blood samples difference value interindividual variability fluence covariate infusion period ampicillin estimate pharmacol delivery change group disease bootstrap error variability nonmem fi ltration rate oedema signi ficant effect netherland clearance mdrd formula figure creatinine pharmacokinetic parameters amoxicillin pharmacokinetics prevention serum goodness-of -fit plots dosing point amount interindividual signi fi nal model interval terminal half-life data points formula bootstrap analysis individual concentration –time sampling muller method centre blood pressure blood fl ow speci fic drugs rotterdam account serum creatinine function signi ficance level mic value 1 g amoxicillin