Voskuyl, R.A.

concentration patient model umbilical amoxicillin pharmacokinetic labour serum study blood population sample clindamycin venous umbilical cord parameter women venou antibiotic umbilical cord analysis value distribution interindividual variability estimate blood samples volume infusion variability disease protein binding neonate netherland nonmem agents chemother fi nal model delivery error liter covariate pregnancy interindividual binding compartment protein mother interval goodness-of -fit plots ratio group administration difference effect onset dosing postpartum period gbs disease /liter pharmacokinetic parameters ef ficacy level prevention umbilical cord serum sampling library erasmus mc postpartum peak concentration simulation birth muller serum concentrations fetus clearance agent fluence umbilical cord blood antimicrob period ampicillin signi 30 min