Budde, K.

patient concentration study transplantation transplant mycophenolate tacrolimu mycophenolate mofetil impdh group exposure mycophenolic pharmacokinetic rejection mycophenolic acid transplant recipients mofetil activity recipient mpa exposure ec-mp impdh activity month mpa auc 0–12 sample difference table polymorphism transplant patients analysis kidney cyp 3a value cyclosporine drug monitoring method enteric-coated mycophenolate sodium cyp 3a genotype plasma result 0–12 incidence genotype therapy model predose assay trial monitoring mpa-auc level mpa-auc 0 –12 center day 3 cyp 3a expressers department number point population roche sampling protein mpa auc university mpa concentrations event effect relationship figure allele diarrhea hoffmann-la roche ltd variability target enzyme blood cyp 3a nonexpressers time points monophosphate mycophenolic acid exposure