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-21 il -21 transplantation patient t-cell culture expression donor rejection t cells il -2 response level cytokine ctlpf number chain transplant proliferation function production cd 8+ gls study population proliferative stimulation presence allograft reactivity cd 4+ gls antibody donor antigens donor-speci proliferative response ifn -␥ blood immunosuppression antigen effect interleukin lymphocytes control il -21 pathway rpmi 1640- dm donor-specific kidney cytotoxic immunol graft range result aza dose control group figure anti-il donor-specific ctlp pathway analysis heart month effector stimulator cells donor-speci fic ctlpf tnf -␣ gl cultures cd 3+ pbmc allogeneic responses cd 8 t-cells anti-cd tnf -␣ production ifn-c mrna expression levels antidonor gl populations organ transplantation spleen activity biopsy spleen cells t-cell reactivity
4 Most Recent Publications
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Deficient TNF-α and IFN-γ production correlates with nondetectable donor-specific cytotoxicity after clinical kidney transplantation
(Article)
Besouw, N.M. van Kuiper, R. de Mast, B.J. van der Wetering, J. van de Baan, C.C. Weimar, W. |
2009-05-27
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Donor-specific immune regulation by CD8+ lymphocytes expanded from rejecting human cardiac allografts
(Article)
Dijke, I.E. Caliskan, K. Klepper, M. Kuiper, R. de Balk, A.H.M.M. Maat, A.W.P.M. Weimar, W. Baan, C.C. |
2009-02-01
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After discontinuation of calcineurin inhibitors, tapering of mycophenolate mofetil further impairs donor-directed cytotoxicity
(Article)
Besouw, N.M. van Wetering, J. van de Mast, B.J. van der Kuiper, R. de Baan, C.C. Weimar, W. |
2008-03-01
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Interleukin-21: An interleukin-2 dependent player in rejection processes
(Article)
Baan, C.C. Balk, A.H.M.M. Dijke, I.E. Korevaar, S.S. Peeters, A. Kuiper, R. de Klepper, M. Zondervan, P.E. Maat, L.A.P.W.M. Weimar, W. |
2007-06-01
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