Ng, Y.Y.

vector expression protein leukemia therapy lentiviral patient level figure gene therapy blood b cells assay fusion transplantation ficiency number immunobead development lentiviral vectors spleen sffv.corag result insertional mutagenesis b-cell antibody serum btk à/à mice analysis bcr –abl promoter fl ow cytometry sample transfer integration rag 1 expression t-cell 1-/- protease t cells animal ficiency yy ng reconstitution immunode insertional ficient kinase detection signi btk expression tyrosine mutagenesi myeloid transduced spleen cells lysate model transcript transgene control value schmidt m transduction sffv.corag 1-treated mice sequence 19.cobtk lentiviral gene therapy immunode ficiency cell lines efs.cobtk correction mouse immunobead assay lentiviral gene transfer 4 1 c rag 1à/à mice il 2rg cd 19.cobtk x-linked cytometric