Dietrich, P-Y.

methylation patient glioblastoma tumor glioma trial promoter model status survival treatment probe fication cancer value classi temozolomide phase chemotherapy dataset oncol outcome methylated mgmt methylation classi fication prediction mgmt methylation status mgmt promoter methylation anaplastic therapy mgmt-stp agent sample -450k probability methylation status grade hm -450k mgmt-stp 27 expression response figure 1.0 bene fit 0.0 0.8 mgmt-stp 27 model adjuvant 0.6 0.4 0.2 mgmt promoter study island brain analysis alkylating radiotherapy region van den unmethylated alkylating agent therapy effect month −glioma brain tumors neuropathol association platform proportion oligodendroglioma cohort stupp schedule mgmt status anaplastic glioma maintenance randomized university hm -27k