Goorden, S.M.I.

mitochondrial protein syndrome mitophagy embryo figure brain tuberous sclerosis pathway mitochondria mouse rheb ϫ/ϫ embryos mutation patient activity control synaptic metabolism study kinase tuberou sclerosis glutamine tsc 1ϩ/ϫ mice mechanism synaptic plasticity neuron activation function condition degradation receptor result phosphorylation plasticity target factor mitochondrial degradation deficit treatment genetics vol .24 model memory hela cells growth expression hamartoma syndromes autism effect development energy analysis wild-type inhibitor oxidative hamartoma number tsc 1 e 11.5 embryos tsc 1ϩ/ϫ mutants ras –erk pathway glucose rapamycin level rheb 1 cancer oxphos activity interaction platform tsc patients phenotype increase oxpho change speci myc-rheb noonan genet pi 3k oxidative conditions