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patient study statin fh patients cholesterol statin treatment disease polymorphism treatment level chd risk hypercholesterolemia mutation heart disease xanthoma association effect heart population atherosclerosi genotype variant result lipoprotein receptor kastelein jj factor risk factors ldlr mutation analysis allele lipid cohort individual plasma table model number analyses efflux chapter rotterdam study rotterdam difference kastelein van aalst-cohen es subject alox 5ap gene interaction abca 1 cholesterol efflux event hazard group reduction artery disease hdl-c pathway smoking genet heart disease risk tendon xanthomas presence protein apolipoprotein family tt individuals haplotype concentration genome-wide sample control macrophage ldlr gene p-value signi person <0.001 chd risk reduction ratio
9 Most Recent Publications
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Coronary Heart Disease in Familial Hypercholesterolemia
(Doctoral Thesis)
Versmissen, J. |
2012-09-19
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Low-density lipoprotein receptor mutations generate synthetic genome-wide associations
(Article)
Oosterveer, D.M. Versmissen, J. Kastelein, J.J.P. Aulchenko, Y.S. Sijbrands, E.J.G. Defesche, J.C. Sivapalaratnam, S. Yazdanpanah, M. Mulder, M. Zee, L. van der Uitterlinden, A.G. Tikka-Kleemola, P. Hofman, A. |
2012-09-12
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A frequent variant in the ABCA1 gene is associated with increased coronary heart disease risk and a better response to statin treatment in familial hypercholesterolemia patients
(Article)
Versmissen, J. Oosterveer, D.M. Yazdanpanah, M. Mulder, M. Dehghan, A. Defesche, J.C. Kastelein, J.J. Sijbrands, E.J.G. |
2011-02-01
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The risk of tendon xanthomas in familial hypercholesterolaemia is influenced by variation in genes of the reverse cholesterol transport pathway and the low-density lipoprotein oxidation pathway
(Article)
Oosterveer, D.M. Versmissen, J. Yazdanpanah, M. Defesche, J.C. Kastelein, J.J. Sijbrands, E.J.G. |
2010-04-01
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Differences in characteristics and risk of cardiovascular disease in familial hypercholesterolemia patients with and without tendon xanthomas: A systematic review and meta-analysis
(Article)
Oosterveer, D.M. Versmissen, J. Yazdanpanah, M. Hamza, T.H. Sijbrands, E.J.G. |
2009-12-01
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5-Lipoxygenase activating protein (ALOX5AP) gene variants associate with the presence of xanthomas in familial hypercholesterolemia
(Article)
Oosterveer, D.M. Versmissen, J. Yazdanpanah, M. Net, J.B. van der Defesche, J.C. Kastelein, J.J. Sijbrands, E.J.G. |
2009-09-01
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Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and coronary heart disease risk in familial hypercholesterolemia
(Article)
Net, J.B. van der Versmissen, J. Kastelein, J.J. Sijbrands, E.J.G. Oosterveer, D.M. Defesche, J.C. Yazdanpanah, M. Aouizerat, B.E. Steyerberg, E.W. Malloy, M.J. Pullinger, C.R. Kane, J.P. |
2009-04-01
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Efficacy of statins in familial hypercholesterolaemia: A long term cohort study
(Article)
Versmissen, J. Oosterveer, D.M. Sijbrands, E.J.G. Yazdanpanah, M. Defesche, J.C. Basart, D.C.G. Liem, A.H. Heeringa, J. Witteman, J.C.M. Lansberg, P.J. Kastelein, J.J. |
2009-01-24
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Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia
(Article)
Net, J.B. van der Oosterveer, D.M. Kane, J.P. Sijbrands, E.J.G. Versmissen, J. Defesche, J.C. Yazdanpanah, M. Aouizerat, B.E. Steyerberg, E.W. Malloy, M.J. Pullinger, C.R. Kastelein, J.J. |
2008-09-01
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