Aanstoot, H.J.

diabetes type 1 diabetes islet antibody patient protein study insulin autoantibodie b-cell antigen disease membrane diabetes mellitus mellitu fraction result gh treatment control level group analysis serum expression acid decarboxylase molecule pancreatic system treatment brain decarboxylase gad 65 individual type 1 onset neuron phase 38 kd protein autoimmunity month autoantigen children syndrome destruction proinsulin mechanism baekkeskov class t-cell assay pancreas enzyme method response population b-cell destruction rat islets value effect tolerance target incidence gad 55 sample stiff-man immunoprecipitation -100 period factor t 1d patients gad 55 antibodies introduction buffer development vesicle process remission peptide marker epitope