Rooij, F.W.M. de

patient mutation cancer disease family syndrome card 15 mutations study cancer risk polyposi polyps peutzejeghers syndrome pjs patients crohn 1007f proband l 1007fs analysis population peutzejegher control table vitamin peutz-jeghers syndrome carriage carcinoma netherland allele article bowel relative cancer risks peutz –jeghers syndrome erythropoietic protoporphyria protoporphyria adenocarcinoma carrier result genet surveillance lkb 1 bowel disease medicine erythropoietic peutz-jegher gastroenterology mortality association family history dutch deletion cohort peutz number frequency gastroenterol expression protoporphyrin history liver www.molmed.org 11/lkb ferrochelatase card 15 mutation university proof polymorphism level difference phenotype fech gene cox 2 deficiency germline prevalence review center colorectal member period