Tissing, W.J.E.

patient glucocorticoid expression receptor study polymorphism resistance level leukemia childhood prednisolone lymphoblastic leukemia protein gc resistance children cancer apoptosi glucocorticoid receptor gene glucocorticoid receptor blood lymphoblastic effect variant leukemic sensitivity exposure gr gene sample prednisolone exposure mutation glucocorticoid resistance response leukemic cells result treatment group chapter table factor folate mthfr binding promoter gr-alpha control pathway figure probe splice .001 analysis prednisone function den boer ml gc exposure variation pieters r difference glucocorticoid-induced apoptosis population mrna expression levels pieter glucocorticoid therapy therapy gr-beta transcription molecule domain gc sensitivity prednison transcript number expression levels mechanism regulation activity leukemic cell lines genotype relation dexamethasone