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globin expression locus signal mouse transcription transgene result figure level liver region probe control analysis number fragment effect promoter position grosveld chromatin globin gene transcript transcriptional deletion element globin genes erythroid erythroid cells wijgerde globin locus hypersensitive liver cells sequence hybridization acids research activation nuclease b globin locus percentage development apovldl dnase protein intron mechanism interaction regulation table hypersensitive sites competition blood adult transcript signals copy number copy numbers nf-l gene b globin gene chromatin structure structure assay activity globin gene expression fraser research factor heterochromatin elongation background concentration table i distance stroubouli dillon 5 hs 3 model γ genes tissue presence
10 Most Recent Publications
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Activation of the beta β globin locus by transcription factors and chromatin modifiers.
(Article)
McMorrow, T. Wijngaard, A. van den Trimborn, T. Lohuizen, M. van Jenuwein, T. Djabali, M. Philipsen, J.N.J. Fraser, P. Grosveld, F.G. Milot, E. |
2000-01-01
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Mechanisms of developmental control of transcription in the murine alpha- and beta-globin loci
(Article)
Trimborn, T. Gribnau, J.H. Fraser, P. Grosveld, F.G. |
1999-01-01
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Chromatin interaction mechanism of transcriptional control in vivo.
(Article)
Gribnau, J.H. Boer, E. de Trimborn, T. Wijgerde, M.G.J.M. Milot, E. Fraser, P. Grosveld, F.G. |
1998-10-15
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Evaluation of β-globin gene therapy constructs in single-copy transgenic mice.
(Article)
Ellis, J. Tan-Un, K.C. Pasceri, P. Harper, A. Wu, X. Fraser, P. Grosveld, F.G. |
1997-01-01
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The effect of distance on long-range chromatin interactions.
(Article)
Dillon, N. Trimborn, T. Strouboulis, J. Fraser, P. Grosveld, F.G. |
1997-01-01
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The dynamics of gene expression: frequency and duration of transcription.
(Article)
Milot, E. Strouboulis, J. Fraser, P. Trimborn, T. Wijgerde, M.G.J.M. Boer, E. de Langeveld, A. Tan-Un, K. Vergeer, W. Yannoutsos, N. Grosveld, F.G. |
1996-10-01
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A dominant chromatin opening activity in 5' hypersensitive site 3 of the human β-globin locus control region.
(Article)
Ellis, J. Tan-Un, K.C. Harper, A. Michalovich, D. Fraser, P. Yannoutsos, N. Grosveld, F.G. |
1996-01-01
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The role of EKLF in human β-globin gene competition.
(Article)
Wijgerde, M.G.J.M. Gribnau, J.H. Trimborn, T. Nuez, B. Philipsen, J.N.J. Grosveld, F.G. Fraser, P. |
1996-01-01
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Transcription complex stability and chromatin dynamics in vivo.
(Article)
Grosveld, F.G. Wijgerde, M.G.J.M. Fraser, P. |
1995-01-01
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Each hypersensitive site of the human β-globin Locus Control Region confers a different developmental pattern of expression to the globin genes.
(Article)
Antoniou, M. Grosveld, F.G. Pruzina, S. Fraser, P. |
1993-01-01
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