Debiec-Rychter, M.

patient imatinib cancer tumor mutation study stromal tumors stromal analysis expression treatment response chromosome smoking pharmacokinetic survival therapy group disease tumours result grade research protein sarcoma lch cells tissue university stromal tumours progression lesion cyp 1a resistance trial langerhans cell histiocytosis smoker cd 1a imatinib mesylate table level factor kinase fbxw 7 gene metastatic oncol effect biopsy j clin oncol array bone sarcoma group department phase genomic prognostic sample geurts van kessel langerhan histiocytosi progression-free survival fi nding nonsmokers article inhibitor pdgfra breakpoint european alteration number nding mesylate cancer research gist patients correlation hospital recist curettage translocation pathology association lch biopsies