Hasty, P.

repair ercc 1-xpf damage cancer 1-xpf dsb repair mutation phenotype senescence dna damage mechanism pathway defect recombination telomere protein lesion double-strand deletion mouse genome ercc 1ϫ/⌬ mice response 86ϫ/ϫ cause function maintenance ficient model ercc 1ϫ/ϫ cells syndrome ageing nature dna repair break 2004. hoeijmaker science 2007. ercc 1 broblast human genome maintenance ercc 1-xpf cells table signi ficantly overhang apoptosi fi broblasts exhibit dna dsbs cell biol endonuclease ficiency sensitivity replication chromosomal increase mouse models ercc 1ϫ/ϫ mefs plasmid mammal 2006. growth genes dev chromosome genomic signi u.s.a ku 86ϫ/ϫ cells embo j ercc 1ϫ/ϫ result dna repair pathways chromosomal aberrations level telomerase isoform accumulation dna-pkc