Campisi, J.

genome science maintenance dna damage phenotype genome maintenance defect cancer mouse repair damage lesion mutation human telomere senescence ku 80 model transcription article www.sciencemag.org nature cause mouse models –/– ku 80–/– mice recombination syndrome exhibit growth response life-span protein symptom function dna lesions table double-strand ttd mice instability mtr –/– mice increase genomic february u.s.a system progeroid syndromes oxidative double-strand lesions progeroid replication helicase degeneration ataxia result disorder genome maintenance systems genome rearrangements pathway deletion mutant individual genomic instability excision apoptosi alopecia p 53 activity metabolism dna excision repair cataract cancer incidence 80–/– downloaded patient mouse mutants atm –/– mice atrophy growth arrest genome maintenance defects nr nr nr