Ding, M.

trabecular modulu model property volume matrix fraction density bisphosphonate trabecular bone tissue structure matrix modulus bone volume fraction subchondral volume fraction sample group osteoarthritis cancellou study cartilage plate change feature result subchondral bone plate model method increase treatment structure model index control element effect direction thickness cartilage damage architecture texture features mineralization texture fracture specimen trabecular thickness cancellous bone anisotropy testing 0.001 level bone mass trabecular architecture e ffect classi microdamage damage alendronate osteoporosis risedronate bone mineral density variance degree surface table erosion collagen connectivity trabecular number stage tissue modulus bone density stress fferent subchondral bone plate parameter fication stiffness connectivity density function difference