Weyts, F.A.A.

osteoblast response level culture stretch phosphorylation bone cells matrix strain 1/2 mg 63 cells differentiation factor erk 1/2 phosphorylation integrin osteogenic factors di fferentiation fferentiation extracellular matrix pathway protein activation signi osteogenic loading proliferation avb 3 integrin hfo cells study formation experiment signal osteoblastic kinase presence erk phosphorylation interaction donor osteoblastic cells extracellular effect apoptosi mechanotransduction day 14 medium signi ficantly cell numbers graft control expression number activity osteocyte stimulation mineralization integrin-matrix interactions antibody erk 1/2-p levels di fferentiating 21 days stage density osteoblast differentiation phosphatase activity mitogen-activated protein kinase absence donor cells dexamethasone b-glycerophosphate stimuli stress apoptotic fferentiating 60 min rgd peptides erk 1/2 strain levels avb 3 5 min tissue