Kooij, V.

heart protein phosphorylation heart failure failure filament cardiomyocyte troponin function force sarcomeric myocardium kinase myo filament signi ficantly myosin 2þ sensitivity signi muscle mlc 2 phosphorylation troponin i change isoform sarcomeric function donor dysfunction non-failing tissue model difference animal sarcomeric proteins protein kinase ficantly erasmus university rotterdam patient sensitivity 2?-sensitivity effect reduction expression force development figure study sample circulation activity end-stage velden myo filament function fi lament stiffness increase analysis sarcomeric dysfunction boontje nm mouse phosphatase end-stage heart failure chain cmybp-c phosphorylation status infarction cardiomyocyte stiffness alteration contractile myo filament proteins tension tombe pp development pca 50 zaremba r physiol disease foetal ctnt pka-mediated phosphorylation motil myo filament dysfunction foetal shift