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patient ebv-specific ebv load number infection t cells virus t-cell ebv reactivation response study blood individual tetramer figure reactivation aids-nhl epstein-barr assay lymphocytes epstein-barr virus analysis ebv-specific t cells time point point epitope ebv-lpd progressor tetramer t cells function cytotoxic month aids-nhl patients control gag-specific recipient gag-specific ctl responses lytic elispot assay disease time points j exp med staining level course percentage lymphoma recovery follow-up value sample immunodeficiency count panel increase peptide tetramer staining transplantation 1000 geq /ml elispot donor lymphoproliferative serum hiv infection 6 months subject result hiv-infected individuals group diagnosis t cell function progression graft cell transplantation hiv individuals j virol antigen seroconversion development range