Lochmüller, E.M.( E.M. Lochmüller)
osteoblast 1/2 erk 1/2 phosphorylation phosphorylation level differentiation stretch osteogenic factors matrix osteogenic strain factor extracellular matrix culture loading pathway erk 1/2-p levels response effect extracellular density protein presence osteoblast differentiation day 14 5 min 60 min erk 1/2 phosphorylated erk 1/2 signal erk 1/2 levels mineralization 21 days cell density expression activation bone cells kinase study experiment osteoblastic signi sv-hfo signi ﬁcantly stage stretch-induced 1/2-p rubin phosphorylated dna levels collagen increase phosphatase activity difference group erk-p /erk ratio extracellular signal-regulated kinase erk 1/2 pathway glucocorticoid-induced osteoblast differentiation mitogen-activated protein kinase differentiation stage osteoblastic cells osteocyte calcium cell cultures medium period formation sv-hfo cells activity cyclic mechanotransduction cyclic stretch baseline plate absence ﬁ broblasts mc 3t cells chiba tissue
1 Most Recent Publications
The osteoporotic vertebral structure is well adapted to the loads of daily life, but not to infrequent "error" loads
Homminga, J. Rietbergen, B. van Lochmüller, E.M. Weinans, H.H. Eckstein, F. Huiskes, R.