Lochmüller, E.M.

osteoblast 1/2 erk 1/2 phosphorylation phosphorylation level differentiation stretch osteogenic factors matrix osteogenic strain factor extracellular matrix culture loading pathway erk 1/2-p levels response effect extracellular density protein presence osteoblast differentiation day 14 5 min 60 min erk 1/2 phosphorylated erk 1/2 signal erk 1/2 levels mineralization 21 days cell density expression activation bone cells kinase study experiment osteoblastic signi sv-hfo signi ficantly stage stretch-induced 1/2-p rubin phosphorylated dna levels collagen increase phosphatase activity difference group erk-p /erk ratio extracellular signal-regulated kinase erk 1/2 pathway glucocorticoid-induced osteoblast differentiation mitogen-activated protein kinase differentiation stage osteoblastic cells osteocyte calcium cell cultures medium period formation sv-hfo cells activity cyclic mechanotransduction cyclic stretch baseline plate absence fi broblasts mc 3t cells chiba tissue