http://repub.eur.nl/res/aut/18428/ List of Publications en http://repub.eur.nl/static-eur/img/logo.png http://repub.eur.nl http://repub.eur.nl/res/pub/15733/ 2001-04-23T00:00:00Z Purpose: The aim of this study was to determine the additional value of magnetic resonance imaging (MRI) in the knee joint of patients with multiple epiphyseal dysplasia (MED) type 2 compared with conventional radiographic examination. Methods: Six individuals with MED (mean age 12.7 years) underwent investigation of their knee joints with conventional radiography and MRI. Results: As in conventional radiographs, MRI images showed irregular and delayed ossification of the epiphyses; articular cartilage had a normal appearance. Conclusion: Magnetic resonance imaging did not reveal specific abnormalities in patients with MED type 2 compared with conventional radiographs. The indications for MRI in patients with MED are the same as in patients without this condition. http://repub.eur.nl/res/pub/15543/ 1998-11-01T00:00:00Z Twenty-seven painful knee replacements were evaluated arthroscopically. The diagnostic and therapeutic value of these arthroscopic procedures was studied retrospectively. In 5 of the 27 cases, the arthroscopy revealed no diagnosis for the pain. Some form of arthroscopic treatment was performed in 20 cases; in 6 of these 20 cases, however, the treatment did not reduce the pain. Based on these findings, we conclude that the indications for arthroscopic evaluation and treatment of painful knee prostheses are limited. http://repub.eur.nl/res/pub/17514/ 1998-09-09T00:00:00Z Multiple epiphyseal dysplasia (MED) is one of the most common osteochondrodysplasias [Wynne-Davies and Gormley 1985]. During childhood and adolescence it affects the epiphyses of the tubular bones, resulting in axial deformities and shorter limbs.·Later in life MED can lead to osteoarthritis. The disease has been given its name by Sir Thomas Fairbank in 1947 [Fairbank 1947]. The diagnosis is based on physical examination and radiological survey. Radiographic abnonnalities appear after the third year of life. The most important finding is the delay and irregularity of ossification of the involved epiphyses. The epiphyses of all long bones can be affected. Radiographic anthropometric studies have been performed, being of value in early diagnosis of lvfED in case of doubt [Poznanski et al. 1972, lngram 1992]. The disease is inherited and affects both sexes. The type of inheritance is autosomal dominant. Histology of cartilage of patients with MED reveals paucity of chondrocytes in all zones of the growth plate as well as loss of orientation of the chondrocytes [Anderson et a1. 1962]. These changes, however, are similar to those seen in other osteochondrodysplasias. Electron microscopical studies have shown dilations of rough endoplasmic reticulum containing a material with alternately wide electron dense and electron lucent layers [Stanescu et al. 1993]. Treatment is symptomatic. Tn case of limited range of motion physical therapy and nonsteroidal anti-inflammatory drugs may be prescribed; in case of axial deformities osteotomies can be performed (Chapler 1) http://repub.eur.nl/res/pub/15526/ 1990-01-01T00:00:00Z