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treatment patient psoriasis dermatol study liposomes laser light therapy vitiligo lesion effect plaque pdl treatment result cancer 5- ala liposomal improvement photodynamic therapy figure acne vulgaris khellin application dye laser side effects cream epidermal blister photodynamic disease dermatology expression psoriatic vulgari lipid uorescence wavelength system factor epidermis fluorescence plaque type psoriasis table skin cancer transplantation fl uorescence score graft penetration actinic melanocyte vessel molecule tissue spray change leeuw target combination carcinoma energy response encapsulated delivery keratinocyte number 5- aminolevulinic acid membrane preparation stratum corneum technique vegfr behandeling stratum method level sebaceou group damage